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35 Alternatively, reporting of neurochemical levels relative to a reference neurochemical in the same voxel is a common approach, as measurements are technologically uncomplicated (only a single spectrum must be collected) and no correction for partial-volume effects is required

Compounds such as resveratrol, curcumin, quercetin, EGCG, berberine, baicalein, polydatin, and phlorizin activate AMPK-SIRT1/PGC-1 and PI3K-Akt pathways, enhance mitochondrial biogenesis and bioenergetics, suppress NF-B/NLRP3 driven neuroinflammation, reduce ROS production, and improve insulin responsiveness

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In addition, it mirrors the pattern of cell death that seen in humans, with a greater impact on the SN pars compacta compared to the ventral tegmental area (German et al

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